AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |
Back to Blog
Anti photonium xt charge3/20/2023 ![]() ![]() YTB323, an investigational, autologous CD19-directed CAR-T cell therapy developed using the T-Charge platform, showed promising results in the diffuse large B-cell lymphoma arm of a first-in-human, multicenter, Phase I dose-escalation study. “We are encouraged by these promising early clinical data from the first CAR-T cell therapies produced using the T-Charge platform as we look to accelerate their development and delivery to patients.” Our ambition now is to go beyond incremental advances, to further reimagine CAR-T cell therapy and give patients a higher likelihood of durable responses with the ultimate potential for a cure,” said Jay Bradner, President of the Novartis Institutes for BioMedical Research. “With T-Charge, we aim to build on the vast knowledge gleaned from early investment in CAR-T research and trials. These unique characteristics of the T-Charge platform may lead to better and more durable responses, improved long-term outcomes and a reduced risk of severe adverse events 1 - 4. With T-Charge, CAR-T cell expansion occurs primarily within a patient’s body (in-vivo), eliminating the need for an extended culture time outside of the body (ex-vivo) 3 ,4. The T-Charge platform preserves T cell stemness, the ability to self-renew and mature, which results in a product containing greater proliferative potential and fewer exhausted T cells 3 ,4. ![]() For the 11 patients with multiple myeloma who received the two highest doses of PHE885, the best overall response was 100% 2. Notably, initial efficacy data show a complete response rate of 73% (95% CI: 44.9, 92.2) at month three for the 15 patients with diffuse large B-cell lymphoma (DLBCL) who received dose level two of YTB323 1. At the 63rd American Society of Hematology Annual Meeting & Exposition (ASH) 2021, Novartis will present early clinical data from ongoing Phase I clinical trials with YTB323 (anti-CD19) and PHE885 (anti-BCMA), the first Novartis CAR-T cell therapies developed using this platform. With the implementation of important process efficiencies, the T-Charge platform will be rapid, compared with traditional CAR-T, and reliable, through simplified processes and streamlined quality control 1-4īasel, DecemNovartis today announced the introduction of T-Charge™, the company’s next-generation CAR-T platform that will serve as the foundation for various new investigational CAR-T cell therapies in the Novartis pipeline.Novartis continues to accelerate development of the T-Charge platform, which preserves T cell stemness, an important characteristic closely tied to its therapeutic potential, and implements important process efficiencies 3 ,4.Initial efficacy results include 73% complete response rate at month three with dose level two in the YTB323 study in DLBCL and 100% best overall response in the PHE885 study in multiple myeloma 1,2.Early data from first-in-human dose-escalation trials with YTB323 and PHE885 show promising results that support ongoing research and development with the hope of improving upon existing CAR-T therapies 1,2. ![]() T-Charge, a next-generation platform that aims to revolutionize CAR-T cell therapy, will serve as foundation for various investigational CAR-T therapies. ![]()
0 Comments
Read More
Back to Blog
R studio ggplot3/20/2023 ![]() ![]() Ggplot(aes(x = Year, y = Avg_Life_Expec)) We are trying to look at life expectancy through time, so this means that Year will go to the x-axis and Avg_Life_Expec will go to the y-axis. ![]() aes is short for “aesthetic”, and it is where we tell ggplot what columns we want to use for different parts of the plot. In order to specify the axes, we need to use the aes() function. We are interested in looking at how life expectancy changes with time, so this indicates what our two axes are: Year and Avg_Life_Expec. The next layer that we need to establish are the axes. ![]() Now that we’ve prepared the data, we can start building our visualization. But it now “knows” to use the life_expec data, even though we don’t see it charted yet. This code produces a blank graph (as we see below). We use the ggplot() function to indicate that we want to create a plot. The data is in a good place, so we can pipe it into a ggplot() function to begin creating a graph. For this visualization, we’ll focus on the United States overall, so we’ll need to filter the data down accordingly: life_expec %įilter(Race = "All Races", Sex = "Both Sexes") One year has nine different rows, each one corresponding to a different demographic division. # Year Race Sex Avg_Life_Expec Age_Adj_Death_Rate library(tidyverse)įor the year 2000, there are nine data points: # A tibble: 9 x 5 We have our data named as life_expec.csv, so you’ll need to rename it according to how you name the file. We’ll bring in the tidyverse packages and use the read_csv() function to import the data. In order to start on the visualization, we need to get the data into our workspace. As you continue reading through the post, keep these layers in mind. The ggplot2 package is one of the packages in the tidyverse, and it is responsible for visualization. The labels or annotations that will help a reader understand the plot:īreaking down a plot into layers is important because it is how the ggplot2 package understands and builds a plot.The geometric shapes used to visualize the data.We can break down this plot into its fundamental building blocks: There are many types of visualizations out there, but most of them will boil down to the following: (Not sure how you can work with R on your personal computer? Check out how to get started with RStudio!) What’s in a Graph?īefore we dive into the post, some context is needed. If you’d like to reproduce the graphs we’ll create in this blog post, download the data set here and follow along! With advances in medicine and technology, we would expect that life expectancy would be increasing, but we won’t know for sure until we have a look! We would like to know how life expectancy has been changing through time. They’ve compiled data on life expectancy and death rate of United States citizens. The National Center for Health Statistics has been tracking United States mortality trends since 1900. To work through it, it’s best if you already have an understanding of R programming syntax, but you don’t need to be an expert or have any prior experience working with ggplot2. In this blog post, we’ll learn how to take some data and produce a visualization using R. And thankfully for data analysts and data scientists who use R, there’s a tidyverse package called ggplot2 that makes data visualization a snap! We visualize data because it’s easier to learn from something that we can see rather than read. The same thing is often true for data - and that’s where data visualization with ggplot2 comes in! The course will not go into detail about how the data management works behind the scenes.Sketching out the design for a house communicates much more clearly than trying to describe it with words. The focus in this course learning to use ggplot2 to make a variety of visualizations and to polish those visualizations using tools within ggplot as well as vector graphics editing software. It is intended for learners who have either have some experience with R and data wrangling in the tidyverse or have taken the previous course in the specialization. This course is the second in a specialization in Data Visualization offered by Johns Hopkins. However, R can be intimidating for first time users, and there are so many resources online that it can be difficult to sort through without guidance. Especially in conjunction with the tidyverse software packages, R has become an extremely powerful and flexible platform for making figures, tables, and reproducible reports. One of the critical tools for data visualization today is the R statistical programming language. Data visualization is a critical skill for anyone that routinely using quantitative data in his or her work - which is to say that data visualization is a tool that almost every worker needs today. ![]()
Back to Blog
23 parsecs toau3/20/2023 ![]()
Back to Blog
![]() ![]() Users of Twitch, the world's biggest video game streaming site, staged a virtual walkout last month to voice outrage over barrages of racist, sexist and homophobic abuse on the platform. The person who posted the trove of stolen data left a message claiming the break-in was performed to foster competition in video streaming, and because the Twitch community "is a disgusting toxic cesspool," according to media reports. The hacker took more than 125 gigabytes of data in the breach, according to the 4chan post. "With such a concerning data breach from a platform as widespread and global as Twitch, users are naturally wanting to protect themselves and their data as soon as possible," an N.Rich spokesperson said. Google searches for "how to delete Twitch" rocketed eightfold as news of the hack spread, according to marketing analysts firm N. ![]() It did not appear that personal Twitch user data was in the dump, but the extent of the hack was still being investigated. A post at 4Chan served up 125 gigabytes of data reported to include Twitch source code, records of payouts to streamers, and a digital video game distribution service being built by Amazon Game Studios. The statement came after reports emerged that a massive dump of Twitch data had been posted on fringe anonymous message board 4Chan. "Our teams are working with urgency to understand the extent of this." "We can confirm a breach has taken place," Twitch said in post from its verified Twitter account. The site is primarily focused on videos and livestreams for video game enthusiasts. ![]() In addition, it offers music broadcasts, creative content, and more confirmed the break-in on Twitter. Amazon bought Twitch for almost $1 billion in 2014. The platform, where users often stream live video game play, including broadcasts of E-sports competitions. ![]()
Back to Blog
Lightgallery options3/19/2023 ![]() ![]() Easy to set up, implement, and customize.You can learn more about how to use the plugins, props, higher-order components, and React Hook by visiting the React Lightgallery documentation. The React Lightgallery package also provides access to a React higher-order component ( withLightgallery), and a React Hook ( useLightgallery) for use inside of. Explore Tauri, a new framework for building binaries.Discover how to animate your React app with AnimXYZ.Switch between multiple versions of Node.Use React's useEffect to optimize your application's performance.Learn how LogRocket's Galileo cuts through the noise to proactively resolve issues in your app. ![]()
Back to Blog
Speedify for mac os x 10.7.53/19/2023 ![]() ![]() The main application window is elegant and has a well-organized structure that invites you to point to images by dragging and dropping them in the designated area. However, it also comes with useful extra tools like an image recorder and converter. Crack is a comprehensive software application for creating virtual disks and mounting images. We also offer dedicated servers that are 1Gbps.DAEMON Tools Ultra 6. our public servers can handle speeds between 200-300Mbps (some servers might do more), so you shouldn't be seeing a drop to 6Mbps. My first suggestion would be to change to a different transport mode in Speedify to see if that makes a difference. Could you also send us a copy of your Speedify logs after doing a few speed tests so we could figure out what the problem might be? If I see correctly, you've already sent us the speed test results you see to our support inbox. We would love to help you resolve this issue. I'm sorry to hear you've been having issues with Speedify's performance lately. I will be submitting a request to Apple for a refund. Support is not helpful and just wanted to blame the connections, but the whole point is they work GREAT without Speedify, so, really, that’s just an excuse. This is across devices, across locations (where I also tested the connection), and across accounts (both mine and my wife’s) and has been going on for about the last month. When I use Speedify, it maxes out at 6mbps up and down, VERY inconsistently. When I don’t use Speedify, it tests VERY consistently at this speed, no problem. The last month, they have oversubscribed the service or cut costs and infrastructure, I can’t be sure, but what I know and is indisputable: my connection right now can do 300Mbps up and down no problem (actually, it’s way faster, but my WiFi connection maxes at 300Mbps). Title says it all: this used to be a very fast, good service. Used to be amazing, now oversubscribed: I get 300+ mbps without it, down to 6mbps with it! – Any unused portion of a free trial period, if offered, will be forfeited when the user purchases a subscription to that publication, where applicable No cancellation of the current subscription is allowed during active subscription period Subscriptions may be managed by the user and auto-renewal may be turned off by going to the user's Account Settings after purchase Account will be charged for renewal within 24-hours prior to the end of the current period, and identify the cost of the renewal Subscription automatically renews unless auto-renew is turned off at least 24-hours before the end of the current period Payment will be charged to iTunes Account at confirmation of purchase Speedify for Families plans include iCloud Family Sharing that lets you and five other family members share access. Or, treat your entire family to faster, more reliable Internet. Upgrade to get Unlimited Access for just $14.99 per month or $89.99 per year (Save 50%!) Speedify subscriptions provide unlimited usage, access to all of our server locations, and can be used on up to 5 devices at a time. We’ll secure and optimize your first two gigabytes of Internet activity across all available connections every month for free! We do not log the IP addresses of websites that you visit or the contents of data sent or received through our service. Speedify doesn’t just offer protection from the outside, we respect your privacy too. Speedify runs in the background, encrypting the data transmitted for ALL of your apps, so you stay safe whether you’re browsing, shopping, or livestreaming. Speedify uses the accelerated encryption from Apple's processors to deliver a fast, secure connection. Speedify automatically prioritizes audio and video streams and dynamically adjusts to network conditions so you can stop asking "Can you Hear Me?" and start streaming at the speed of all your connections combined! Test your Internet connections before you go live to find your optimal livestreaming resolution and frames per second! Hate when your audio stops or video pauses because you stepped a few feet outside of your Wi-Fi range? Speedify bonds your cellular and Wi-Fi connections together and will seamlessly shift your web traffic between them as necessary without missing a beat or skipping a frame. MORE RELIABLE INTERNET - WHEREVER YOU GO! ![]() Speedify's unique channel bonding technology allows you to use all available Internet connections including Wi-Fi, Cellular, Ethernet, Tethered Phones, Starlink, and Satellite connections at the same time to optimize performance. USE MULTIPLE INTERNET CONNECTIONS AT THE SAME TIME Speedify is the only app that can combine multiple internet sources into one bonded super-connection for more stable and secure livestreaming, video calling, gaming, and web browsing. ![]()
Back to Blog
Torchlight 3 enchanting altar3/19/2023 ![]() ![]() There must be an unequipped version still in your inventory for this to work. Equip one of the items you want to make permanent. Use the "Duplicate items" trick with a bow an arrows to duplicate the items to make permanent. You can use the "Duplicate items" trick to make as many as desired, then sell them. However, the item once made permanent cannot be re-equipped, but each enchanted item is different. You can duplicate a drop-able item, and if that item is equipable with constant effect enchantments you can make them permanent. Use the following trick for duplication or a permanent enchantment. Note: Do not try to duplicate more than 250 copies of an item or the game may freeze. This works with most, but not all, items and weapons. The amount of copies of an item you make depends on how many arrows you have equipped. You can pick up all the duplicates and use or sell them. The item that you dropped will be duplicated. Drop the item, then leave the equipment screen and resume the game. Select the arrows that you are using, then go to the item to be duplicated. While it is drawn back, go to the inventory screen. From: andre.morgan Duplicate itemsĮquip a bow and any set of arrows, then draw your bow back. Your enemies will also just stand still unable to attack, allowing you to go into Sneak mode and attack for 4x to 6x damage, and pickpocket without consequence (except on guards who can catch you if you fail, but still cannot attack you if you resist arrest). You can now steal from a shop without the shopkeepers doing anything. Each enchantment gives you 20% Chameleon effect, so all five enchantments will make you 100% Chameleon, which is not only invisible but also allows you to attack, steal, open, and pick-up without being revealed. Go to an enchanting stand and enchant the necklace, rings, and armor with a Chameleon spell using the Grand Soul Gems. Go to the Chironasium (enchanting section) in Arcane University. This trick requires access to Arcane University, a Chameleon spell, two rings, a necklace/amulet, any two pieces of armor (preferably a helmet and shield you could use any armor for this, but you may want to enchant them with defensive magic later), five Grand Soul Gems with Grand Souls in them, and 8,000 gold. ![]()
Back to Blog
Stick rpg 2 directors cut full screen3/19/2023 ![]() Given his new superhuman condition, Jensen is just the right guy to sleuth that out. He is told that his ex-girlfriend, Megan, and her research team were killed in the attack, and CEO David Sarif wants answers regarding who was behind the strike and why. Sarif’s head of security, Adam Jensen, is critically wounded and wakes to find himself having gone through severe augmentation in order to save his life. Detroit’s Sarif Industries is one of the corporate biotech giants whose technology is among those leading the charge, and as it prepares to send its CEO along with a group of scientists to a congressional hearing in Washington, D.C., the company suffers a deadly attack by a group of unknown mercenaries. Set in the year 2027, a whole 25 years prior to the original Deus Ex, the events of Human Revolution unfold during an incredibly exciting time in its cyberpunk world: Biomechanical augmentation is on the rise, and along with it comes exploration of the philosophical quandary around what it means to be human. Now patched up, polished and fully augmented to take advantage of its new hardware home, a console whose interface-extending GamePad can itself be considered an augmentation by traditional console standards, the Wii U edition of Deus Ex: Human Revolution Director’s Cut stands as the definitive version of one of the best games of its generation. Square-Enix's idea to bring Eidos Montreal’s swell Deus Ex: Human Revolution to the Wii U over two full years after the game first saw light of day on Xbox 360, PS3 and PC is a curious resurrection, perhaps, but given the quality of protagonist Adam Jensen’s cyberpunk caper the title deserves as big of an audience as it can get. ![]()
Back to Blog
Utc time zone to mst3/19/2023 ![]() To convert MST to CST, you have to add one hour. Mountain Standard Time (MST) is 1 hour behind Central Standard Time (CST).To convert MST to EST, you have to add two hours. Mountain Standard Time (MST) is 2 hours behind Eastern Standard Time (EST).Converting Mountain Time to Other US Time Zones Most North American time zones also have generic terms, including Pacific Time (PT), Central Time (CT), Eastern Time (ET), and Atlantic Time (AT). This can add a bit of confusion as the term Mountain Time does not differentiate between standard time and Daylight Saving Time, so Mountain Time switches between MST and MDT in areas that use DST during part of the year. In everyday usage, MST is often referred to as Mountain Time (MT) or the Mountain Time Zone. John, and Dawson Creek use Mountain Standard Time all year. Some areas in British Coloumbia, including Creston, Fort Nelson, Fort St. Mountain Daylight Time (MDT) is used during the remainder of the year. Mountain Standard Time (MST) is a standard time zone in use from the first Sunday in November to the second Sunday in March-when Daylight Saving Time (DST) is not in effect. ![]() In North America, Mountain Standard Time shares a border with Central Standard Time (CST) in the east and with Pacific Standard Time (PST) in the west. It spans from northern Canada to Mexico near the equator. The MST time zone is the least populated time zone in the USA. It covers all or parts of 13 states in the US and five provinces or territories in Canada. ![]() Mountain Standard Time is the second westernmost time zone in the United States and Canada. See full time zone map What Is Mountain Standard Time? This time zone is in use during standard time in: North America. ![]() Mountain Standard Time (MST) is 7 hours behind Coordinated Universal Time (UTC). Observes MST – Mountain Standard Time part of the year, but not currently.Ĭurrently has same time zone offset as MST (UTC -7) but different time zone name.
Back to Blog
Cd labeler deluxe edition3/19/2023 ![]() ![]() Use our store locator to check if zero-contact collection is offered at your chosen store. Save CD Edicin de lujo - Death Cab For Cutie. When you do come to collect your item(s) make sure you bring this confirmation email, and the last four digits of your payment/gift card or voucher. Popular Schools Miles Davis - Session in the ring - Deluxe Edition. ![]() OJOsoft WMA to MP3 Converter 1.5 download, buy StairCon 3.40 SP3, purchase audit 7. Once you’ve selected “collect in store” at the online checkout, we’ll email you your confirmation & collection details. order Surething CD DVD Labeler Deluxe Edition 5.1, Posted by tolinka at 7:51 PM No comments: cheap Traktor DJ Studio 3.4. britain and america hail to the chiefs books and arts. SureThing CD Labeler Deluxe Edition By MicroVision Development Free to try Download Now Developer's Description By MicroVision Development SureThing, is a CD/DVD Labeling Software, lets you create. the sleeper and the spindle deluxe edition neil gaiman. ![]() gold dust woman a biography of stevie nicks by stephen davis. Pop in store to collect your items within an hour of ordering them, free of charge (depending on stock availability). surething cd labeler deluxe edition free download and. soundgarden-telephantasm-cd-1-2010-deluxe-edition pres .rar. There are two options available to you: in-store pick up and drive-thru collection. SureThing CD DVD Labeler Deluxe v5.1.614.0 + LightScribe update 1.18.5.1.rar. You can now order your item(s) online, and safely collect them from your chosen store within an hour of placing your order. You can let us know at the checkout for any limitionations (e.g. If you're getting a large item delivered to a room or flat above the first floor of your home or block, our team will only be able to decide if they can safely deliver it when they arrive. PC CD - ROM Uniblue Powersuite 2012 ( bhv ) License for 3 Pcs Nip AU 33.81 AU 8.20 postage or Best Offer Australian Card Maker Deluxe - PC Windows AU 9. The Complete Package includes installation CD, labels and label applicator. You can use the availaility checker to quickly find out about stock availability and delivery information. Supports all major label brands, LightScribe and direct-to-disc inkjet printers. Try it 15 days for free File size: 13.1 MB Buy Now. Supports all major label brands, LightScribe and direct-to-disc inkjet printers. Weekend and next-day delivery is available in most areas, but not all.Īnd, of course, delivery is always dependent upon stock availability. Deluxe Edition The new SureThing CD/DVD Labeler v5.2 Deluxe Edition is the easiest way to create stunning, professional-looking labels. Our Track It service also allows you to see where your order is at. A scheduled task is added to Windows Task Scheduler in order to launch the program at various scheduled times (the schedule varies depending on the version). Make sure to add your mobile number when you place your order, so we can text you with delivery updates. ![]() |